Connect with others who understand.

sign up log in
About MyHemophiliaTeam

Hemophilia Types

Updated on August 13, 2018

Article written by
Kelly Crumrin

Types of hemophilia and other bleeding disorders are defined by which clotting factor (or factors) is too low or ineffective in their bodies. In some cases, hemophilia types are also defined by what causes the bleeding disorder. Knowing which type of bleeding disorder a person has is necessary to ensure effective treatment.

Types of Bleeding Disorders

Bleeding disorders are genetic conditions unless otherwise specified. In most types, severity is based on the level of clotting factor activity; lower levels of factor activity usually mean more severe disease.

Von Willebrand Disease (VWD)

VWD is the most common of all bleeding disorders. Those with VWD lack von Willebrand factor and can have low levels of factor VIII. One in 100 people may have a form of VWD. There are three subtypes of von Willebrand disease that describe severity: type 1, type 2, and type 3. Type 1 is the mildest and most common, involving low levels of factor and accounting for as many as 75 percent of cases. In type 2, clotting factors may or may not be low, but they do not work effectively. Type 2 may account for 20 to 25 percent of cases and has several subtypes. In type 3 von Willebrand disease – the most severe type – clotting factor may be almost nonexistent. Only 1 in 1 million people have type 3 VWD.

Hemophilia A

In hemophilia A, also known as classic hemophilia, people lack factor VIII. About 1 in 5,000 males have hemophilia A. About 60 percent of people with hemophilia A have the most severe form of the disease.

Hemophilia B

People with hemophilia B – also called Christmas disease – lack factor IX. About 1 in 25,000 males have hemophilia B. About 60 percent of people with hemophilia B have the most severe form of the disease. Hemophilia B Leyden, a rare form that affects 3 percent of those with hemophilia B, causes a pattern of bleeding episodes in childhood that subsides after puberty. People with hemophilia B Leyden have extremely low levels of factor IX in childhood that gradually increase as the person ages. As adults, some people with hemophilia B Leyden reach near-normal levels of factor and may no longer require treatment for their bleeding disorder.

Acquired Hemophilia

Some people are not born with congenital hemophilia but develop it later in life as a result of another health condition or a medication. Acquired hemophilia, which can be very severe, affects between 1 and 1.5 people per 1 million. Unlike most other types of bleeding disorders, acquired hemophilia can sometimes go away if the underlying problem – health condition or medication – is resolved.

Factor I Deficiency

Factor I deficiency is a collection of disorders called congenital fibrinogen defects. Mild cases of factor I deficiency affect about 1 in 1 million people. The severe form, afibrogenemia, affects about 5 in 10 million.

Factor II Deficiency

Factor II deficiency affects approximately 1 in 2 million. Factor II deficiency, also referred to as prothrombin deficiency, may be inherited or acquired due to liver disease, lack of vitamin K, or the effects of blood thinner medications. Factor II deficiency is usually mild.

Factor V Deficiency

Usually mild, factor V deficiency affects approximately 1 in 1 million.

Factor VII Deficiency

Affecting about 1 in 500,000 people, factor VII deficiency can range from mild to severe depending on factor levels. Factor VII deficiency may be inherited or acquired due to liver disease, vitamin K, or the effects of blood thinner medications.

Factor X Deficiency

Approximately 1 in 1 million people have factor X deficiency, which can range from moderate to severe. Factor X deficiency is also known as Stuart-Prower deficiency.

Factor XI Deficiency

Factor XI deficiency is also referred to as hemophilia C. About 1 in 100,000 people have factor XI factor deficiency, which usually ranges from mild to moderate.

Factor XIII Deficiency

When it occurs, factor XIII deficiency is severe. Luckily it is also extremely rare – about 1 in 3 million people have factor XIII deficiency.

Combination Deficiencies

Rarely, some people have deficiencies of more than one clotting factor. Deficiency in factors V and VIII may be the most common combination deficiency. In combined V and VIII deficiency, the body makes these two factors, but is unable to transport the clotting factor into the blood.

Extremely rarely, some people are deficient in all clotting factors that are dependent on vitamin K, which include factors II, VII, IX, and X. This condition, known as vitamin K-dependent clotting factor deficiency, may be passed on in families or acquired as a result of liver failure, lack of vitamin K, or overdose of warfarin, a blood thinner medication. It is not known how many people might have vitamin K-dependent clotting factor deficiency.

Condition Guide

Resources

External resources

Kelly leads the creation of content that educates and empowers people with chronic illnesses. Learn more about her here.

A MyHemophiliaTeam Member said:

Im so sorry your going through all that, it's insane how many injuries you have at once..
It's insane we have to deal with these asshole doctors all the… read more

posted 12 months ago

hug

Recent articles

Ajax loader trans
Article written by Kelly Crumrin Those of us living with pre-existing, chronic conditions such as...

Canceling Is Kindness: Keeping Safe From COVID-19 With Hemophilia

Article written by Kelly Crumrin Those of us living with pre-existing, chronic conditions such as...
Ajax loader trans
Eat healthier. Exercise more. Learn a new skill. Pay off a credit card. Many of us have made...

Setting Intentions for 2020 With Hemophilia

Eat healthier. Exercise more. Learn a new skill. Pay off a credit card. Many of us have made...
Ajax loader trans
This time of the year can be overwhelming with expectations around the holidays, and living with...

Practicing Gratitude With Hemophilia

This time of the year can be overwhelming with expectations around the holidays, and living with...
Ajax loader trans
Living with or caring for someone with hemophilia may change your holidays, but you can still...

Enjoying the Holidays While Living With Hemophilia

Living with or caring for someone with hemophilia may change your holidays, but you can still...
Ajax loader trans
We all respond differently to information about our health. After learning you or a loved one has...

You’ve Just Been Diagnosed With Hemophilia. Now What?

We all respond differently to information about our health. After learning you or a loved one has...
Ajax loader trans
There is an old saying: “Good fences make good neighbors.” Having healthy boundaries in...

How Good Boundaries Make Life With Hemophilia Easier

There is an old saying: “Good fences make good neighbors.” Having healthy boundaries in...
Ajax loader trans
Thousands of members of MyHemophiliaTeam connect with one another and read each other's stories...

Four Books About Hemophilia You Should Read

Thousands of members of MyHemophiliaTeam connect with one another and read each other's stories...
Ajax loader trans
Many members on MyHemophiliaTeam describe challenges in talking to their doctors about bleeding...

Talking to Doctors About Hemophilia Symptoms

Many members on MyHemophiliaTeam describe challenges in talking to their doctors about bleeding...
Ajax loader trans
Living with a bleeding disorder sometimes means living with fear. MyHemophiliaTeam members...

Hemophilia and Living With Fear

Living with a bleeding disorder sometimes means living with fear. MyHemophiliaTeam members...
Ajax loader trans
Living with hemophilia or caring for someone with a bleeding disorder can mean having limited...

Tap Into the Power of Directness: Use "I"

Living with hemophilia or caring for someone with a bleeding disorder can mean having limited...
MyHemophiliaTeam My hemophilia Team

Two Ways to Get Started with MyHemophiliaTeam

Become a Member

Connect with others who are living with hemophilia. Get members only access to emotional support, advice, treatment insights, and more.

sign up

Become a Subscriber

Get the latest articles about hemophilia sent to your inbox.

Not now, thanks

Privacy policy
MyHemophiliaTeam My hemophilia Team

Thank you for signing up.

close